Prascend packaging in a pink box Prascend packaging in a pink box

PRASCEND® (pergolide tablets)

Managing PPID When Every Day Counts

Pituitary pars intermedia dysfunction (PPID), formerly known as equine Cushing’s disease, is a progressive neurodegenerative disorder in horses. This means the pituitary gland can’t keep bodily functions in a healthy working state, resulting in a variety of clinical signs. PPID is also associated with several serious conditions, including laminitis, secondary infections and insulin dysregulation.

Talk to your veterinarian about PRASCEND tablets, the most trusted treatment for managing the clinical signs associated with PPID.1Download the PPID Checklist for a complete list of clinical signs to look out for and discuss with your veterinarian.

Top Reasons to Choose PRASCEND

By controlling hormone production, PRASCEND helps manage the clinical signs of PPID, and has been veterinarians’ most trusted treatment for more than a decade.

A horse owner caring for her horse, smiles at her horse’s clinical signs of PPID improve after using the Prascend treatment. A horse owner caring for her horse, smiles at her horse’s clinical signs of PPID improve after using the Prascend treatment.

Controlled Signs

Clinical signs began to improve within three months and continued to improve through six months.1

A horse owner feeds the horse after a successful Prascend treatment. A horse owner feeds the horse after a successful Prascend treatment.

Proven Success

Three out of four horses evaluated were considered treatment successes.1

A close-up shot of a horse’s coat illustrating an improvement of delayed shedding after the Prascend treatment. A close-up shot of a horse’s coat illustrating an improvement of delayed shedding after the Prascend treatment.

Clear Improvement

Delayed shedding (hypertrichosis) improved in 89% of treated horses within six months.1

How PRASCEND Controls PPID

In horses with PPID, the pituitary gland overproduces hormones. PRASCEND acts to curb the overproduction and secretion of these hormones, which helps to better manage the clinical signs of PPID.

PRASCEND Made the Difference for Spirit

Stacie and Tony Richmond saw changes in their 9-year-old horse, Spirit, from weight gain and irritability to trouble losing his winter coat. See how they’re managing the clinical signs of PPID with PRASCEND treatment.

Additional Product Information

Dosage & Administration

PRASCEND tablets are available with a prescription by a veterinarian, but can be administered by a horse owner. Administer orally at a starting dose of 2mcg/kg once daily. Single-scored tablets make it simple to adjust dosage. Dosage may be adjusted to effect, not to exceed 4 mcg/kg daily. 

For more information, please read the PRASCEND product insert

Resources
Safety

Storage: Store at or below 25ºC (77ºF) 

IMPORTANT SAFETY INFORMATION: PRASCEND is for use in horses only. PRASCEND has not been evaluated in breeding, pregnant or lactating horses. Treatment with PRASCEND may cause loss of appetite. Most cases are mild. If severe, a temporary dose reduction may be necessary. Weight loss, lack of energy, and behavioral changes also may be observed. PRASCEND tablets should not be crushed due to the potential for increased human exposure. Pregnant or lactating women should wear gloves when administering this product. PRASCEND is contraindicated in horses with hypersensitivity to pergolide mesylate or other ergot derivatives. Keep PRASCEND in a secure location out of reach of dogs, cats, and other animals to prevent accidental ingestion or overdose. Dogs have eaten PRASCEND tablets that were placed in food intended for horses or dropped during administration of the tablets to the horses. Adverse reactions may occur if animals other than horses ingest PRASCEND tablets. Refer to the package insert for complete product information. 

References

1 PRASCEND [Freedom of Information Summary]. St. Joseph, MO: Boehringer Ingelheim Vetmedica, Inc. 2016. 

 

PRASCEND® is a registered trademark of Boehringer Ingelheim Vetmedica GmbH, used under license. ©2025 Boehringer Ingelheim Animal Health USA Inc., Duluth, GA. All rights reserved. US-EQU-0103-2024

IMPORTANT SAFETY INFORMATION: PRASCEND treatment may cause loss of appetite. Most cases are mild. If severe, a temporary dose reduction may be necessary. Weight loss, lack of energy, and behavioral changes also may be observed. PRASCEND tablets should not be crushed due to the potential for increased human exposure. PRASCEND is for use in horses only. Not for use in humans. Do not ingest the product. Pergolide, like other ergot derivatives, may cause emesis, dizziness, lethargy or low blood pressure. Pregnant or lactating women should wear gloves when administering this product. Store this product separately away from human medicinal products and handle this product with care to avoid accidental ingestion. Keep PRASCEND in a secure location out of reach of dogs, cats, and other animals to prevent accidental ingestion or overdose. Dogs have eaten PRASCEND tablets that were placed in food intended for horses or dropped during administration of the tablets to the horses. Adverse reactions may occur if animals other than horses ingest PRASCEND tablets. PRASCEND is contraindicated in horses with hypersensitivity to pergolide mesylate or other ergot derivatives. PRASCEND has not been evaluated in breeding, pregnant, or lactating horses. Refer to the package insert for complete product information. Refer to the package insert for complete product information.