Equioxx (firocoxib) Tablets for horses, a non-steroidal anti-inflammatory drug, shown in bottles and packaging. Equioxx (firocoxib) Tablets for horses, a non-steroidal anti-inflammatory drug, shown in bottles and packaging.

EQUIOXX® (firocoxib)

Managing Joint Pain

Osteoarthritis (OA) is the progressive deterioration of the joint, also referred to as degenerative joint disease (DJD). It is a common condition, and can occur in all types and ages of horses. With OA, your horse may show heat or swelling of the joint, stiffness, decreased mobility or lameness. 

You can help manage the joint pain and inflammation associated with OA using EQUIOXX tablets, a market-leading treatment proven to deliver pain relief with just once daily dosing.1 Talk to your veterinarian to find out if EQUIOXX tablets are right for your horse.

Learn More About Joint Health

Top Reasons To Choose EQUIOXX

For treatment of joint pain associated with osteoarthritis, EQUIOXX has been veterinarians’ trusted choice to help your horse escape the shadows of joint disease. As a pioneering pain management product approved by the FDA, EQUIOXX has been proven safe and effective.

Equioxx (firocoxib) 57 mg chewable tablets for horses, in a white bottle on a bed of hay. Equioxx (firocoxib) 57 mg chewable tablets for horses, in a white bottle on a bed of hay.

Proven

EQUIOXX has more safety data than any other equine NSAID,1,2 and a decreased potential for risks commonly associated with nonselective NSAIDs, like phenylbutazone (also known as bute).2

Women riding a brown horse patting it as it starts to turn Women riding a brown horse patting it as it starts to turn

Consistent

With just once a day dosing, EQUIOXX controls pain and inflammation associated with osteoarthritis.1

Close up of a horse's mouth eating Equioxx from someone's hand. Close up of a horse's mouth eating Equioxx from someone's hand.

Convenient

EQUIOXX tablets can be hand-fed with or without feed.

Understanding different kinds of NSAIDs infographic Understanding different kinds of NSAIDs infographic

Powerful Where Needed, Gentle Where It Counts

EQUIOXX is designed to relieve pain and inflammation in your horse—with less interference with important functions like blood clotting, gastrointestinal and kidney health. Unlike non-selective pain relievers like phenylbutazone, which block both helpful and harmful pathways, EQUIOXX focuses on the ones that cause discomfort, helping reduce the risk of side effects. This means that EQUIOXX has a decreased potential for risks commonly associated with selective NSAIDs like phenylbutazone.*3,4

Roz and the Journey to Recapture His Drive

When Roz began struggling to pick up the canter, Jeremy Frederick, DVM, DACVIM, diagnosed him with early-onset osteoarthritis. What would that mean for his comfort level and career as a dressage horse?

Additional Product Information

Dosage & Administration

EQUIOXX is sold by prescription only, but is made for easy administration by an owner.

The recommended dosage of EQUIOXX tablets is one 57-mg tablet administered orally to horses weighing 800–1,300lbs, (0.04–0.07mg/lb or 0.09–0.15mg/kg), once daily for up to 14 days. 

For more information, please read EQUIOXX Tablets Product Insert.

Resources

EQUIOXX Tablets Prescribing Information 

EQUIOXX Brochure

Safety

IMPORTANT SAFETY INFORMATION: As with any prescription medication, prior to use, a veterinarian should perform a physical examination and review the horse’s medical history. A veterinarian should advise horse owners to observe for signs of potential drug toxicity. As a class, nonsteroidal anti-inflammatory drugs for horses may be associated with gastrointestinal, hepatic and renal toxicity. Use with other NSAIDs, corticosteroids or nephrotoxic medication should be avoided. EQUIOXX has not been tested in horses less than 1 year of age or in breeding horses, or pregnant or lactating mares.

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References

* Clinical relevance has not been established.

1 EQUIOXX product labels and FOI summaries and supplements.

2 Kvaternick V, Pollmeier M, Fischer J, Hanson PD. Pharmacokinetics and metabolism of orally administered firocoxib, a novel second-generation coxib, in horses. J Vet Pharmacol Ther 2007;30(3):208–217. 

3 Data on file at Boehringer Ingelheim.

4 Warner TD, Mitchell JA. Cyclooxygenase-3 (COX-3): Filling in the gaps toward a COX continuum? Commentary 2022;99(21):13371–13373. 

 

EQUIOXX® is a registered trademark of Boehringer Ingelheim Animal Health USA Inc. ©2025 Boehringer Ingelheim Animal Health USA Inc., Duluth, GA. All rights reserved. US-EQU-0106-2025

IMPORTANT SAFETY INFORMATION: As with any prescription medication, prior to use, a veterinarian should perform a physical examination and review the horse’s medical history. A veterinarian should advise horse owners to observe for signs of potential drug toxicity. As a class, nonsteroidal anti-inflammatory drugs may be associated with gastrointestinal, hepatic and renal toxicity. Use with other NSAIDs, corticosteroids or nephrotoxic medications should be avoided. EQUIOXX has not been tested in horses less than 1 year of age or in breeding horses, or in pregnant or lactating mares.